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HLF and hTERT cooperatively enable partial immortalization of human hematopoietic stem and progenitor cells

Hematopoietic stem and progenitor cells (HSPCs), residing at the apex of the hematopoietic hierarchy, are critical for the generation of all blood and immune cell lineages. This unique capacity makes HSPCs indispensable for advancing cell and gene therapies aimed at correcting defects across hematop...

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Bibliografische Detailangaben
Hauptverfasser: Manoj Kumar K. Azhagiri, Els Verhoeyen, Kumarasamypet Murugesan Mohankumar, Srujan Kumar Marepally, Vigneshwaran Venkatesan, Saravanabhavan Thangavel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2026-01-01
Schriftenreihe:Frontiers in Bioengineering and Biotechnology
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Online-Zugang:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1731355/full
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