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HLF and hTERT cooperatively enable partial immortalization of human hematopoietic stem and progenitor cells

Hematopoietic stem and progenitor cells (HSPCs), residing at the apex of the hematopoietic hierarchy, are critical for the generation of all blood and immune cell lineages. This unique capacity makes HSPCs indispensable for advancing cell and gene therapies aimed at correcting defects across hematop...

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Principais autores: Manoj Kumar K. Azhagiri, Els Verhoeyen, Kumarasamypet Murugesan Mohankumar, Srujan Kumar Marepally, Vigneshwaran Venkatesan, Saravanabhavan Thangavel
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-01-01
coleção:Frontiers in Bioengineering and Biotechnology
Assuntos:
Ex vivoHSPC culture
hematopoietic stem and progenitor cells
HLF
immortalization
primary cell-like models
prolonged HSPCs culture, HSPCs immortalization
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1731355/full
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