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Targeting Immune Checkpoints: Basic Signaling Pathways and Clinical Translation in Cancer Therapeutics

ABSTRACT Immune checkpoints, the key gatekeepers of immune homeostasis, have become the central targets of modern cancer immunotherapy. These regulatory pathways, composed of co‐suppressive and co‐stimulatory molecules, enable the immune system to distinguish between self and non‐self while preventi...

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Principais autores: Han Sun, Dan Huang, Huiling Zhang, Mingyuan Dong, Simiao Wang, Man Sun, Jiayi Liu, Yiqi Wang, Xiaojie Qu, Xuefeng Li, Zhaogang Yang
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2025-09-01
Serier:MedComm – Oncology
Fag:
immune checkpoint
immune escape
immunotherapy
monoclonal antibody
Online adgang:https://doi.org/10.1002/mog2.70030
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