Detection of Enriched T Cell Epitope Specificity in Full T Cell Receptor Sequence Repertoires

High-throughput T cell receptor (TCR) sequencing allows the characterization of an individual's TCR repertoire and directly queries their immune state. However, it remains a non-trivial task to couple these sequenced TCRs to their antigenic targets. In this paper, we present a novel strategy to anno...

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Detalhes bibliográficos

Principais autores:	Sofie Gielis, Pieter Moris, Wout Bittremieux, Nicolas De Neuter, Benson Ogunjimi, Kris Laukens, Pieter Meysman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2019-11-01
coleção:	Frontiers in Immunology
Assuntos:	TCR repertoire analysis epitope specificity enrichment analysis immunoinformatics vaccines infectious disease
Acesso em linha:	https://www.frontiersin.org/article/10.3389/fimmu.2019.02820/full
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