Inflammatory perturbations in early life long-lastingly shape the transcriptome and TCR repertoire of the first wave of regulatory T cells

The first wave of Foxp3+ regulatory T cells (Tregs) generated in neonates is critical for the life-long prevention of autoimmunity. Although it is widely accepted that neonates are highly susceptible to infections, the impact of neonatal infections on this first wave of Tregs is completely unknown....

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Hlavní autoři:	Juhao Yang, Mangge Zou, Xiaojing Chu, Stefan Floess, Yang Li, Michael Delacher, Jochen Huehn
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2022-08-01
Edice:	Frontiers in Immunology
Témata:	neonatal perturbations regulatory T cells (Tregs) TCR repertoire single-cell ‘omics long-lasting
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.991671/full
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