SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species

Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs, but the mechanism of action of those potential therapeutic agents remains unknown. Using a genetic screen in haploid human cells, we discovered that the enantiospecific cytotoxicity of numerous termin...

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Bibliographic Details

Main Authors:	Pascal Demange, Etienne Joly, Julien Marcoux, Patrick RA Zanon, Dymytrii Listunov, Pauline Rullière, Cécile Barthes, Céline Noirot, Jean-Baptiste Izquierdo, Alexandrine Rozié, Karen Pradines, Romain Hee, Maria Vieira de Brito, Marlène Marcellin, Remy-Felix Serre, Olivier Bouchez, Odile Burlet-Schiltz, Maria Conceição Ferreira Oliveira, Stéphanie Ballereau, Vania Bernardes-Génisson, Valérie Maraval, Patrick Calsou, Stephan M Hacker, Yves Génisson, Remi Chauvin, Sébastien Britton
Format:	Artigo
Language:	Inglês
Published:	eLife Sciences Publications Ltd 2022-05-01
Series:	eLife
Subjects:	prodrugs short-chain dehydrogenase/reductase chiral cytototoxic lipid endoplasmic reticulum stress unfolded protein response ubiquitin-proteasome system
Online Access:	https://elifesciences.org/articles/73913
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