Effects of the G-quadruplex-binding drugs quarfloxin and CX-5461 on the malaria parasite Plasmodium falciparum

Plasmodium falciparum is the deadliest causative agent of human malaria. This parasite has historically developed resistance to most drugs, including the current frontline treatments, so new therapeutic targets are needed. Our previous work on guanine quadruplexes (G4s) in the parasite's DNA and RNA...

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Principais autores:	Holly M. Craven, Guilherme Nettesheim, Pietro Cicuta, Andrew M. Blagborough, Catherine J. Merrick
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-12-01
coleção:	International Journal for Parasitology: Drugs and Drug Resistance
Assuntos:	Malaria Plasmodium G-quadruplex quarfloxin CX-5461 repositioning
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211320723000404
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