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A G-quadruplex stabilizer, CX-5461 combined with two immune checkpoint inhibitors enhances in vivo therapeutic efficacy by increasing PD-L1 expression in colorectal cancer

Purpose: Immune checkpoint inhibitors (ICIs) alone or in combination with chemotherapy can improve the limited efficacy of colorectal cancer (CRC) immunotherapy. CX-5461 causes substantial DNA damage and genomic instability and can increase ICIs’ therapeutic efficacies through tumor microenvironment...

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Principais autores: Shin-Yi Chung, Yu-Chan Chang, Dennis Shin-Shian Hsu, Ya-Chi Hung, Meng-Lun Lu, Yi-Ping Hung, Nai-Jung Chiang, Chun-Nan Yeh, Michael Hsiao, John Soong, Yeu Su, Ming-Huang Chen
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023-01-01
coleção:Neoplasia: An International Journal for Oncology Research
Assuntos:
CX-5461
G-quadruplex
Colorectal cancer
Immunotherapy
PD-L1
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S1476558622000811
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