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Predicting Complex Traits and Exposures From Polygenic Scores and Blood and Buccal DNA Methylation Profiles

We examined the performance of methylation scores (MS) and polygenic scores (PGS) for birth weight, BMI, prenatal maternal smoking exposure, and smoking status to assess the extent to which MS could predict these traits and exposures over and above the PGS in a multi-omics prediction model. MS may b...

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Principais autores: Veronika V. Odintsova, Valerie Rebattu, Fiona A. Hagenbeek, René Pool, Jeffrey J. Beck, Erik A. Ehli, Catharina E. M. van Beijsterveldt, Lannie Ligthart, Gonneke Willemsen, Eco J. C. de Geus, Jouke-Jan Hottenga, Dorret I. Boomsma, Jenny van Dongen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2021-07-01
coleção:Frontiers in Psychiatry
Assuntos:
DNA methylation
methylation scores
polygenic scores
multi-omics prediction
birth weight
maternal smoking
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fpsyt.2021.688464/full
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