Predicting Complex Traits and Exposures From Polygenic Scores and Blood and Buccal DNA Methylation Profiles

We examined the performance of methylation scores (MS) and polygenic scores (PGS) for birth weight, BMI, prenatal maternal smoking exposure, and smoking status to assess the extent to which MS could predict these traits and exposures over and above the PGS in a multi-omics prediction model. MS may b...

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Bibliografiske detaljer

Principais autores:	Veronika V. Odintsova, Valerie Rebattu, Fiona A. Hagenbeek, René Pool, Jeffrey J. Beck, Erik A. Ehli, Catharina E. M. van Beijsterveldt, Lannie Ligthart, Gonneke Willemsen, Eco J. C. de Geus, Jouke-Jan Hottenga, Dorret I. Boomsma, Jenny van Dongen
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2021-07-01
Serier:	Frontiers in Psychiatry
Fag:	DNA methylation methylation scores polygenic scores multi-omics prediction birth weight maternal smoking
Online adgang:	https://www.frontiersin.org/articles/10.3389/fpsyt.2021.688464/full
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