क्यूआर कोड

A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Abstract Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's disease (HD) is characterized by the intracellular accumulation of mutant huntingtin (mHTT) that can be soluble and aggregated in the central...

पूर्ण विवरण

में बचाया:
मुख्य लेखकों: Caijuan Li, Yingqi Lin, Yizhi Chen, Xichen Song, Xiao Zheng, Jiawei Li, Jun He, Xiusheng Chen, Chunhui Huang, Wei Wang, Jianhao Wu, Jiaxi Wu, Jiale Gao, Zhuchi Tu, Xiao‐Jiang Li, Sen Yan, Shihua Li
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Wiley 2023-11-01
श्रृंखला:Advanced Science
विषय:
HD KI‐140Q mice
intravenous injection
lysosome
mini‐intrabody
mutant huntingtin
SM3
ऑनलाइन पहुंच:https://doi.org/10.1002/advs.202301120
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