A Specific Mini‐Intrabody Mediates Lysosome Degradation of Mutant Huntingtin

Abstract Accumulation of misfolded proteins leads to many neurodegenerative diseases that can be treated by lowering or removing mutant proteins. Huntington's disease (HD) is characterized by the intracellular accumulation of mutant huntingtin (mHTT) that can be soluble and aggregated in the central...

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Autors principals:	Caijuan Li, Yingqi Lin, Yizhi Chen, Xichen Song, Xiao Zheng, Jiawei Li, Jun He, Xiusheng Chen, Chunhui Huang, Wei Wang, Jianhao Wu, Jiaxi Wu, Jiale Gao, Zhuchi Tu, Xiao‐Jiang Li, Sen Yan, Shihua Li
Format:	Artigo
Idioma:	Inglês
Publicat:	Wiley 2023-11-01
Col·lecció:	Advanced Science
Matèries:	HD KI‐140Q mice intravenous injection lysosome mini‐intrabody mutant huntingtin SM3
Accés en línia:	https://doi.org/10.1002/advs.202301120
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