Downregulation of Ripk1 and Nsf mediated by CRISPR-CasRx ameliorates stroke volume and neurological deficits after ischemia stroke in mice

Necroptosis is implicated in the pathogenesis of ischemic stroke. However, the mechanism underlying the sequential recruitment of receptor-interacting protein kinase 1 (RIPK1) and N-ethylmaleimide-sensitive fusion ATPase (NSF) in initiating necroptosis remains poorly understood, and the role of NSF...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Xincheng Song, Yang Lan, Shuang Lv, Yuye Wang, Leian Chen, Tao Lu, Fei Liu, Dantao Peng
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2024-06-01
Schriftenreihe:	Frontiers in Aging Neuroscience
Schlagworte:	CRISPR-CasRx ischemic stroke ripk1 NSF AAV
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fnagi.2024.1401038/full
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!