A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis
Hexokinase 2 expression is markedly induced in cancer cells and contributes to cancer cell metabolism. Here, the authors show that hexokinase 2 can contribute to the metastatic spread of cancer cells independently of its glycolytic function via inhibiting the activity of GSK3β, which in turn elevate...
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| Principais autores: | , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2022-02-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-022-28440-3 |
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