A non-catalytic scaffolding activity of hexokinase 2 contributes to EMT and metastasis

Hexokinase 2 expression is markedly induced in cancer cells and contributes to cancer cell metabolism. Here, the authors show that hexokinase 2 can contribute to the metastatic spread of cancer cells independently of its glycolytic function via inhibiting the activity of GSK3β, which in turn elevate...

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Autors principals:	Catherine S. Blaha, Gopalakrishnan Ramakrishnan, Sang-Min Jeon, Veronique Nogueira, Hyunsoo Rho, Soeun Kang, Prashanth Bhaskar, Alexander R. Terry, Alexandre F. Aissa, Maxim V. Frolov, Krushna C. Patra, R. Brooks Robey, Nissim Hay
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2022-02-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-022-28440-3
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