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Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation

Akt activation in human cancers exerts chemoresistance, but pan-Akt inhibition elicits adverse consequences. We exploited the consequences of Akt-mediated mitochondrial and glucose metabolism to selectively eradicate and evade chemoresistance of prostate cancer displaying hyperactive Akt. PTEN-defic...

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Principais autores: Veronique Nogueira, Krushna C Patra, Nissim Hay
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2018-04-01
Serier:eLife
Fag:
reactive oxygen species
Hexokinase 2
cancer therapy
prostate cancer
Akt
PTEN
Online adgang:https://elifesciences.org/articles/32213
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