Selective eradication of cancer displaying hyperactive Akt by exploiting the metabolic consequences of Akt activation

Akt activation in human cancers exerts chemoresistance, but pan-Akt inhibition elicits adverse consequences. We exploited the consequences of Akt-mediated mitochondrial and glucose metabolism to selectively eradicate and evade chemoresistance of prostate cancer displaying hyperactive Akt. PTEN-defic...

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Váldodahkkit:	Veronique Nogueira, Krushna C Patra, Nissim Hay
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	eLife Sciences Publications Ltd 2018-04-01
Ráidu:	eLife
Fáttát:	reactive oxygen species Hexokinase 2 cancer therapy prostate cancer Akt PTEN
Liŋkkat:	https://elifesciences.org/articles/32213
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