18-β-glycyrrhetinic acid facilitates nuclear-mitochondrial communications to alleviate oxidative stress through HMGB1-cGAS-Mul1 axis in tendinopathy

Abstract Background Tendinopathy is a prevalent orthopaedic condition characterized by disrupted tendon homeostasis, with oxidative stress being a key contributing mechanism. Although the natural compound 18-β-Glycyrrhetinic acid (GA) exhibits antioxidant properties and is a therapeutic candidate fo...

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Detalhes bibliográficos

Principais autores:	Yuan-Yuan Gao, Wen-Shuang Sun, Zi-Ying Sun, Jun-Rui Wang, Zhong-Yang Lv, Yu-Jia Li, Hao-Yuan Tian, Zheng-Yang Bao, Xin-Ran Qiu, Zheng Wang, Shi-Zhong Zheng, Jiang-Juan Shao, Zi-Li Zhang, Jia Meng
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2026-04-01
coleção:	Journal of Translational Medicine
Assuntos:	18-β-Glycyrrhetinic acid Tendinopathy Oxidative stress cGAS-STING NLRP3 inflammasome HMGB1 methylation
Acesso em linha:	https://doi.org/10.1186/s12967-026-08091-4
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