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18-β-glycyrrhetinic acid facilitates nuclear-mitochondrial communications to alleviate oxidative stress through HMGB1-cGAS-Mul1 axis in tendinopathy

Abstract Background Tendinopathy is a prevalent orthopaedic condition characterized by disrupted tendon homeostasis, with oxidative stress being a key contributing mechanism. Although the natural compound 18-β-Glycyrrhetinic acid (GA) exhibits antioxidant properties and is a therapeutic candidate fo...

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Bibliografiske detaljer
Principais autores: Yuan-Yuan Gao, Wen-Shuang Sun, Zi-Ying Sun, Jun-Rui Wang, Zhong-Yang Lv, Yu-Jia Li, Hao-Yuan Tian, Zheng-Yang Bao, Xin-Ran Qiu, Zheng Wang, Shi-Zhong Zheng, Jiang-Juan Shao, Zi-Li Zhang, Jia Meng
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-04-01
Serier:Journal of Translational Medicine
Fag:
Online adgang:https://doi.org/10.1186/s12967-026-08091-4
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