Secondary follicles enable efficient germline mtDNA base editing at hard-to-edit site
Efficient germline mtDNA editing is required to construct disease-related animal models and future gene therapy. Recently, the DddA-derived cytosine base editors (DdCBEs) have made mitochondrial genome (mtDNA) precise editing possible. However, there still exist challenges for editing some mtDNA sit...
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| Principais autores: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2024-06-01
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| Colecção: | Molecular Therapy: Nucleic Acids |
| Assuntos: | |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S216225312400057X |
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