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Supplementation of Oocytes by Microinjection with Extra Copies of mtDNA Alters Metabolite Profiles and Interactions with Expressed Genes in a Tissue-Specific Manner

Mitochondrial DNA (mtDNA) supplementation can rescue poor oocyte quality and overcome embryonic arrest. Here, we investigated a series of sexually mature pigs generated through autologous and heterologous mtDNA supplementation. Brain, liver and heart tissues underwent metabolite profiling using gas...

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Principais autores: Eryk Andreas, Alexander Penn, Takashi Okada, Justin C. St. John
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI AG 2024-11-01
coleção:Biomolecules
Assuntos:
mtDNA
mtDNA supplementation
metabolite profile
gene expression
metabolic pathways
brain
Acesso em linha:https://www.mdpi.com/2218-273X/14/11/1477
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