Discovery of new Schiff bases of the disalicylic acid scaffold as DNA gyrase and topoisomerase IV inhibitors endowed with antibacterial properties

DNA gyrase and topoisomerase IV show great potential as targets for antibacterial medicines. In recent decades, various categories of small molecule inhibitors have been identified; however, none have been effective in the market. For the first time, we developed a series of disalicylic acid methyle...

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Bibliografische Detailangaben

Hauptverfasser:	Lamya H. Al-Wahaibi, Mohamed A. Mahmoud, Hayat Ali Alzahrani, Hesham A. Abou-Zied, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Stefan Bräse, Safwat M. Rabea
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2024-06-01
Schriftenreihe:	Frontiers in Chemistry
Schlagworte:	salicylic acid Cushman Schiff bases antibacterial DNA gyrase
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fchem.2024.1419242/full
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