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Discovery of new Schiff bases of the disalicylic acid scaffold as DNA gyrase and topoisomerase IV inhibitors endowed with antibacterial properties

DNA gyrase and topoisomerase IV show great potential as targets for antibacterial medicines. In recent decades, various categories of small molecule inhibitors have been identified; however, none have been effective in the market. For the first time, we developed a series of disalicylic acid methyle...

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Autors principals: Lamya H. Al-Wahaibi, Mohamed A. Mahmoud, Hayat Ali Alzahrani, Hesham A. Abou-Zied, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Stefan Bräse, Safwat M. Rabea
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2024-06-01
Col·lecció:Frontiers in Chemistry
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fchem.2024.1419242/full
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