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TSP50 facilitates breast cancer stem cell-like properties maintenance and epithelial-mesenchymal transition via PI3K p110α mediated activation of AKT signaling pathway

Abstract Background Studies have confirmed that epithelial-mesenchymal transition (EMT) and cancer stem cell (CSC)-like properties are conducive to cancer metastasis. In recent years, testes-specific protease 50 (TSP50) has been identified as a prognostic factor and is involved in tumorigenesis regu...

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Principais autores: Feng Gao, Sichen Liu, Jing Wang, Gang Wei, Chunlei Yu, Lihua Zheng, Luguo Sun, Guannan Wang, Ying Sun, Yongli Bao, Zhenbo Song
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2024-07-01
coleção:Journal of Experimental & Clinical Cancer Research
Assuntos:
Breast cancer
TSP50
CSC-like properties
EMT
PI3K/AKT pathway
Acesso em linha:https://doi.org/10.1186/s13046-024-03118-4
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