TSP50 attenuates metabolic dysfunction-associated steatotic liver disease via SCD1 degradation-mediated suppression of hepatocyte lipogenesis

Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a major contributor to chronic liver disease worldwide, yet the molecular mechanisms driving its pathogenesis remain incompletely defined. Although dysregulated hepatic lipogenesis is a well-established driver of...

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Principais autores:	Jiujia Liang, Zhihui Luan, Rong Jin, Rina Su, Jiarong Ge, Xiao Tian, Chunxue Niu, Jiawei Li, Xiaoli Li, Feng Gao, Zhenbo Song, Luguo Sun, Guannan Wang, Lihua Zheng, Ying Sun, Lei Liu, Yongli Bao, Shuyue Wang, Xiaoguang Yang
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2026-02-01
Serija:	Cellular & Molecular Biology Letters
Teme:	TSP50 SCD1 Protease MASLD Hepatocyte lipid accumulation
Online dostop:	https://doi.org/10.1186/s11658-026-00859-2
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