TSP50 promotes the Warburg effect and hepatocyte proliferation via regulating PKM2 acetylation
Gao et al. shows that testes-specific protease 50 (TSP50) binds to PKM2 and promotes the Warburg effect by increasing PKM2 K433 acetylation level and PKM2 acetylation site (K433R) mutation remarkably abrogated the TSP50-induced aerobic glycolysis, cell proliferation in vitro and tumor formation in v...
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| Principais autores: | , , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2021-05-01
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| Serier: | Cell Death and Disease |
| Online adgang: | https://doi.org/10.1038/s41419-021-03782-w |
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