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Microglia-derived IL-1β promotes chemokine expression by Müller cells and RPE in focal retinal degeneration

Abstract Background Chemokine signalling is required for the homing of leukocytes during retinal inflammation, and is associated with pathogenesis of diseases such as age-related macular degeneration (AMD). Here, we explore the role of interleukin-1β (IL-1β) in modulating AMD-associated chemokines C...

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Principais autores: Riccardo Natoli, Nilisha Fernando, Michele Madigan, Joshua A. Chu-Tan, Krisztina Valter, Jan Provis, Matt Rutar
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2017-04-01
Serier:Molecular Neurodegeneration
Fag:
Retinal degeneration
Microglia
Interleukin-1β
IL-1β
Chemokines
RPE
Online adgang:http://link.springer.com/article/10.1186/s13024-017-0175-y
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