BAX activation in mouse retinal ganglion cells occurs in two temporally and mechanistically distinct steps

Abstract Background Pro-apoptotic BAX is a central mediator of retinal ganglion cell (RGC) death after optic nerve damage. BAX activation occurs in two stages including translocation of latent BAX to the mitochondrial outer membrane (MOM) and then permeabilization of the MOM to facilitate the releas...

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Hlavní autoři:	Margaret E. Maes, Ryan J. Donahue, Cassandra L. Schlamp, Olivia J. Marola, Richard T. Libby, Robert W. Nickells
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2023-09-01
Edice:	Molecular Neurodegeneration
On-line přístup:	https://doi.org/10.1186/s13024-023-00659-8
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