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Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity.

BACKGROUND:Hepatic gene transfer, in particular using adeno-associated viral (AAV) vectors, has been shown to induce immune tolerance to several protein antigens. This approach has been exploited in animal models of inherited protein deficiency for systemic delivery of therapeutic proteins. Adequate...

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Principais autores: Ashley T Martino, Sushrusha Nayak, Brad E Hoffman, Mario Cooper, Gongxian Liao, David M Markusic, Barry J Byrne, Cox Terhorst, Roland W Herzog
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2009-08-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC2715858?pdf=render
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