Tolerance induction to cytoplasmic beta-galactosidase by hepatic AAV gene transfer: implications for antigen presentation and immunotoxicity.

BACKGROUND:Hepatic gene transfer, in particular using adeno-associated viral (AAV) vectors, has been shown to induce immune tolerance to several protein antigens. This approach has been exploited in animal models of inherited protein deficiency for systemic delivery of therapeutic proteins. Adequate...

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Ngā kaituhi matua:	Ashley T Martino, Sushrusha Nayak, Brad E Hoffman, Mario Cooper, Gongxian Liao, David M Markusic, Barry J Byrne, Cox Terhorst, Roland W Herzog
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Public Library of Science (PLoS) 2009-08-01
Rangatū:	PLoS ONE
Urunga tuihono:	http://europepmc.org/articles/PMC2715858?pdf=render
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!