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PKGPT: Expert-Orchestrated Recursive LLM Agent for Automated NONMEM PopPK Modeling with Human Benchmarking

<b>Background/Objectives:</b> Population pharmacokinetic (PopPK) modeling in NONMEM requires iterative, expertise-dependent workflows. Naïve zero-shot prompting of general-purpose large language models (LLMs) typically produces NONMEM code that fails to execute. This study introduces PKGPT, a recurs...

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Principais autores: Hoyoung Kwack, Hyunseung Kong, Jiwoo Lim, Byoung-Tak Zhang, Jongsung Hahn, Min Jung Chang
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-04-01
Serier:Pharmaceutics
Fag:
population pharmacokinetics
NONMEM
large language model
agentic AI
model automation
recursive self-correction
Online adgang:https://www.mdpi.com/1999-4923/18/4/501
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