PopPK and PBPK Models Guide Meropenem Dosing in Critically Ill Children with Augmented Renal Clearance

<b>Background</b>: Meropenem (MEM) is frequently prescribed for the empirical management of severe infections in the pediatric intensive care unit (PICU). Critically ill children exhibit substantial pharmacokinetic (PK) variability, and current dosing strategies remain inadequately evaluated, partic...

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Váldodahkkit:	Yao Liu, Hua He, Sa-Sa Zhang, Jia Zhou, Jin-Wei Zhu, Jin Xu, Hong-Jun Miao, Ji-Hui Chen, Kun Hao
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	MDPI AG 2025-11-01
Ráidu:	Pharmaceutics
Fáttát:	pediatric intensive care model-informed precision dosing population pharmacokinetic model physiologically based pharmacokinetic model meropenem renal function
Liŋkkat:	https://www.mdpi.com/1999-4923/17/12/1544
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