PopPK and PBPK Models Guide Meropenem Dosing in Critically Ill Children with Augmented Renal Clearance

<b>Background</b>: Meropenem (MEM) is frequently prescribed for the empirical management of severe infections in the pediatric intensive care unit (PICU). Critically ill children exhibit substantial pharmacokinetic (PK) variability, and current dosing strategies remain inadequately evaluated, partic...

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Autors principals:	Yao Liu, Hua He, Sa-Sa Zhang, Jia Zhou, Jin-Wei Zhu, Jin Xu, Hong-Jun Miao, Ji-Hui Chen, Kun Hao
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2025-11-01
Col·lecció:	Pharmaceutics
Matèries:	pediatric intensive care model-informed precision dosing population pharmacokinetic model physiologically based pharmacokinetic model meropenem renal function
Accés en línia:	https://www.mdpi.com/1999-4923/17/12/1544
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