Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells
Presenilin-1 (PS1) is an important determinant of the γ-secretase activity necessary for the generation of β-amyloid (Aβ), likely the central pathogenic molecule in Alzheimer's disease. Most presenilin is rapidly degraded, and determinants of the level of the active cleaved form are unknown. We exam...
Gardado en:
| Principais autores: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Elsevier
2004-12-01
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| Series: | Journal of Lipid Research |
| Assuntos: | |
| Acceso en liña: | http://www.sciencedirect.com/science/article/pii/S0022227520341183 |
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