Fatty acids increase presenilin-1 levels and γ-secretase activity in PSwt-1 cells

Presenilin-1 (PS1) is an important determinant of the γ-secretase activity necessary for the generation of β-amyloid (Aβ), likely the central pathogenic molecule in Alzheimer's disease. Most presenilin is rapidly degraded, and determinants of the level of the active cleaved form are unknown. We exam...

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Hlavní autoři:	Yanzhu Liu, Lin Yang, Karin Conde-Knape, Dirk Beher, Mark S. Shearman, Neil S. Shachter
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2004-12-01
Edice:	Journal of Lipid Research
Témata:	oleic acid linoleic acid emulsion triglycerides cholesterol CHO cells
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S0022227520341183
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