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C9orf72 in myeloid cells prevents an inflammatory response to microbial glycogen

Summary: Gut dysbiosis and neural inflammation occur in patients with amyotrophic lateral sclerosis (ALS), including those with a causal mutation in chromosome 9 open reading frame 72 (C9ORF72). How gut commensals interact with common ALS genotypes to impart risk of neural degeneration remains uncle...

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Principais autores: Blake McCourt, Katelyn Lemr, Shinjon Chakrabarti, Elizabeth Woidke, Sara Ramaiah, Vaidhvi Singh, Naseer Sangwan, J. Mark Brown, Fabio Cominelli, Alex Rodriguez-Palacios, Aaron Burberry
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-02-01
coleção:Cell Reports
Assuntos:
CP: Immunology
CP: Neuroscience
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S221112472501678X
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