The exocyst subunit EXOC2 regulates the toxicity of expanded GGGGCC repeats in C9ORF72-ALS/FTD

Summary: GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How this genetic mutation leads to neurodegeneration remains largely unknown. Using CRISPR-Cas9 technology, we deleted EXOC2, which encodes an...

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Principais autores:	Dilara O. Halim, Gopinath Krishnan, Evan P. Hass, Soojin Lee, Mamta Verma, Sandra Almeida, Yuanzheng Gu, Deborah Y. Kwon, Thomas G. Fazzio, Fen-Biao Gao
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2024-07-01
Series:	Cell Reports
Assuntos:	CP: Neuroscience CP: Cell biology
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S2211124724007034
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