The exocyst subunit EXOC2 regulates the toxicity of expanded GGGGCC repeats in C9ORF72-ALS/FTD

Summary: GGGGCC (G4C2) repeat expansion in C9ORF72 is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). How this genetic mutation leads to neurodegeneration remains largely unknown. Using CRISPR-Cas9 technology, we deleted EXOC2, which encodes an...

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主要な著者:	Dilara O. Halim, Gopinath Krishnan, Evan P. Hass, Soojin Lee, Mamta Verma, Sandra Almeida, Yuanzheng Gu, Deborah Y. Kwon, Thomas G. Fazzio, Fen-Biao Gao
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2024-07-01
シリーズ:	Cell Reports
主題:	CP: Neuroscience CP: Cell biology
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2211124724007034
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