Neuromuscular organoids model spinal neuromuscular pathologies in C9orf72 amyotrophic lateral sclerosis

Summary: Hexanucleotide repeat expansions in the C9orf72 gene are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Due to the lack of trunk neuromuscular organoids (NMOs) from ALS patients’ induced pluripotent stem cells (iPSCs), an organoid system was missin...

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Prif Awduron:	Chong Gao, Qinghua Shi, Xue Pan, Jiajia Chen, Yuhong Zhang, Jiali Lang, Shan Wen, Xiaodong Liu, Tian-Lin Cheng, Kai Lei
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Elsevier 2024-03-01
Cyfres:	Cell Reports
Pynciau:	CP: Neuroscience
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S2211124724002201
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!