Neuromuscular organoids model spinal neuromuscular pathologies in C9orf72 amyotrophic lateral sclerosis

Summary: Hexanucleotide repeat expansions in the C9orf72 gene are the most common cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Due to the lack of trunk neuromuscular organoids (NMOs) from ALS patients’ induced pluripotent stem cells (iPSCs), an organoid system was missin...

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Principais autores:	Chong Gao, Qinghua Shi, Xue Pan, Jiajia Chen, Yuhong Zhang, Jiali Lang, Shan Wen, Xiaodong Liu, Tian-Lin Cheng, Kai Lei
格式:	Artigo
语言:	Inglês
出版:	Elsevier 2024-03-01
丛编:	Cell Reports
主题:	CP: Neuroscience
在线阅读:	http://www.sciencedirect.com/science/article/pii/S2211124724002201
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