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Recent advances in targeting LRRK2 for Parkinson’s disease treatment

Abstract Parkinson’s disease (PD) is a neurodegenerative disease with severe movement problems. Current treatments mainly focus on symptom management by reducing dopaminergic pathways in the brain. Despite these therapies, ongoing disease progression undermines the effectiveness of prevalent approac...

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Autori principali: Mahsa Karami, Pantea Majma Sanaye, Atousa Ghorbani, Roshanak Amirian, Pouya Goleij, Mehregan Babamohamadi, Zhila Izadi
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2025-07-01
Serie:Journal of Translational Medicine
Soggetti:
Parkinson’s disease
LRRK2
Neurodegenerative diseases
Autophagy
PROTAC
Mitochondrial dysfunction
Accesso online:https://doi.org/10.1186/s12967-025-06354-0
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