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Recent advances in targeting LRRK2 for Parkinson’s disease treatment

Abstract Parkinson’s disease (PD) is a neurodegenerative disease with severe movement problems. Current treatments mainly focus on symptom management by reducing dopaminergic pathways in the brain. Despite these therapies, ongoing disease progression undermines the effectiveness of prevalent approac...

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Principais autores: Mahsa Karami, Pantea Majma Sanaye, Atousa Ghorbani, Roshanak Amirian, Pouya Goleij, Mehregan Babamohamadi, Zhila Izadi
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-07-01
coleção:Journal of Translational Medicine
Assuntos:
Parkinson’s disease
LRRK2
Neurodegenerative diseases
Autophagy
PROTAC
Mitochondrial dysfunction
Acesso em linha:https://doi.org/10.1186/s12967-025-06354-0
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