Disruption of fibroblast MYD88 signaling promotes antitumor immunity in pancreatic ductal adenocarcinoma

Summary: Pancreatic ductal adenocarcinoma (PDAC) continues to carry a dismal prognosis. The disease is characterized by a uniquely dense fibrotic matrix generated by cancer-associated fibroblasts (CAFs). We have previously demonstrated that fibroblast-driven chronic inflammation suppresses T cell fu...

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Principais autores:	Maria Korah, Rosyli F. Reveron-Thornton, Mahsa Fallah, Peter Y. Xie, Amanda Gonçalves, Chuner Guo, James P. Agolia, Andrea E. Delitto, Renceh A.B. Flojo, Biren Reddy, Kaylin A. Yip, John M. Lu, Antonio Tomasso, Angela D. Tabora, Jason L. Guo, Khristian E. Bauer-Rowe, Benjamin Pham, Lipika Goyal, Amanda R. Kirane, Gregory W. Charville, Ovijit Chaudhuri, Monica M. Dua, Brendan C. Visser, Byrne Lee, George A. Poultsides, Derrick C. Wan, Jeffrey A. Norton, Deshka S. Foster, Michael T. Longaker, Daniel Delitto
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2025-10-01
coleção:	Cell Reports
Assuntos:	CP: Cancer CP: Immunology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124725011180
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