Disruption of fibroblast MYD88 signaling promotes antitumor immunity in pancreatic ductal adenocarcinoma

Summary: Pancreatic ductal adenocarcinoma (PDAC) continues to carry a dismal prognosis. The disease is characterized by a uniquely dense fibrotic matrix generated by cancer-associated fibroblasts (CAFs). We have previously demonstrated that fibroblast-driven chronic inflammation suppresses T cell fu...

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Principais autores:	Maria Korah, Rosyli F. Reveron-Thornton, Mahsa Fallah, Peter Y. Xie, Amanda Gonçalves, Chuner Guo, James P. Agolia, Andrea E. Delitto, Renceh A.B. Flojo, Biren Reddy, Kaylin A. Yip, John M. Lu, Antonio Tomasso, Angela D. Tabora, Jason L. Guo, Khristian E. Bauer-Rowe, Benjamin Pham, Lipika Goyal, Amanda R. Kirane, Gregory W. Charville, Ovijit Chaudhuri, Monica M. Dua, Brendan C. Visser, Byrne Lee, George A. Poultsides, Derrick C. Wan, Jeffrey A. Norton, Deshka S. Foster, Michael T. Longaker, Daniel Delitto
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2025-10-01
叢編:	Cell Reports
主題:	CP: Cancer CP: Immunology
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2211124725011180
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