ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

Abstract Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer death; identifying PDAC enablers may reveal potential therapeutic targets. Expression of the actomyosin regulatory ROCK1 and ROCK2 kinases increased with tumor progression in human and mouse pancreatic tumors, while elevated...

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Autori principali:	Nicola Rath, Jennifer P Morton, Linda Julian, Lena Helbig, Shereen Kadir, Ewan J McGhee, Kurt I Anderson, Gabriela Kalna, Margaret Mullin, Andreia V Pinho, Ilse Rooman, Michael S Samuel, Michael F Olson
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Springer Nature 2016-12-01
Serie:	EMBO Molecular Medicine
Soggetti:	collagen remodeling extracellular matrix pancreatic cancer ROCK kinases tumor cell invasion
Accesso online:	https://doi.org/10.15252/emmm.201606743
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