Design, synthesis, in vitro and in silico studies of novel piperidine derived thiosemicarbazones as inhibitors of dihydrofolate reductase

Abstract Dihydrofolate reductase (DHFR), an essential enzyme in folate metabolism, presents a promising target for drug development against various diseases, including cancer and tuberculosis. Herein, we present an integrated approach combining in vitro biochemical assays with in silico molecular do...

وصف كامل

التفاصيل البيبلوغرافية

المؤلفون الرئيسيون:	Hina Aftab, Saeed Ullah, Ajmal Khan, Mariya al-Rashida, Talha Islam, Kholood A. Dahlous, Saikh Mohammad, Hamdy Kashtoh, Ahmed Al-Harrasi, Zahid Shafiq
التنسيق:	Artigo
اللغة:	Inglês
منشور في:	Nature Portfolio 2024-09-01
سلاسل:	Scientific Reports
الموضوعات:	DHFR Piperidine Thiosemicarbazones Enzyme inhibition MoLecular docking ADME
الوصول للمادة أونلاين:	https://doi.org/10.1038/s41598-024-72858-2
الوسوم:	إضافة وسم لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!