Design, synthesis, in vitro and in silico studies of novel piperidine derived thiosemicarbazones as inhibitors of dihydrofolate reductase

Abstract Dihydrofolate reductase (DHFR), an essential enzyme in folate metabolism, presents a promising target for drug development against various diseases, including cancer and tuberculosis. Herein, we present an integrated approach combining in vitro biochemical assays with in silico molecular do...

Descripció completa

Dades bibliogràfiques

Autors principals:	Hina Aftab, Saeed Ullah, Ajmal Khan, Mariya al-Rashida, Talha Islam, Kholood A. Dahlous, Saikh Mohammad, Hamdy Kashtoh, Ahmed Al-Harrasi, Zahid Shafiq
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2024-09-01
Col·lecció:	Scientific Reports
Matèries:	DHFR Piperidine Thiosemicarbazones Enzyme inhibition MoLecular docking ADME
Accés en línia:	https://doi.org/10.1038/s41598-024-72858-2
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!