Synthesis, in vitro, and in silico studies of 7-fluorochromone based thiosemicarbazones as α-glucosidase inhibitors

Abstract Increased blood sugar is a typical manifestation of Type-2 Diabetes Mellitus (T2DM), a metabolic disorder that can be effectively managed with the help of α-glucosidase inhibitors. A range of new chromone based thiosemicarbazone derivatives (3a-t) was synthesized and assessed due to their a...

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Autors principals:	Faiqa Noreen, Saeed Ullah, Suraj N. Mali, Ajmal Khan, Javid Hussain, Abdulrahman Alshammari, Norah A. Albekairi, Rahul D. Jawarkar, Susmita Yadav, Ahmed Al-Harrasi, Zahid Shafiq
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-03-01
Col·lecció:	Scientific Reports
Matèries:	7-fluorochromone Thiosemicarbazones α-glucosidase inhibition SAR Molecular docking ADME
Accés en línia:	https://doi.org/10.1038/s41598-025-90156-3
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