Monosubstituted Acetophenone Thiosemicarbazones as Potent Inhibitors of Tyrosinase: Synthesis, Inhibitory Studies, and Molecular Docking

A set of 12 monosubstituted acetophenone thiosemicarbazone derivatives (TSCs) were synthesized and their inhibitory properties toward tyrosinase activity were tested. Moreover, their ability to inhibit melanogenesis in the B16F10 murine melanoma cell line was studied. In order to investigate the nat...

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Autores principales:	Katarzyna Hałdys, Waldemar Goldeman, Natalia Anger-Góra, Joanna Rossowska, Rafał Latajka
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2021-01-01
Colección:	Pharmaceuticals
Materias:	tyrosinase thiosemicarbazones kinetic studies structure–activity relationship (SAR) molecular docking melanogenesis
Acceso en línea:	https://www.mdpi.com/1424-8247/14/1/74
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