AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation
This study shows that TPX2 co-overexpression in non-transformed human cells induces AurkA nuclear accumulation and promotes its non-mitotic oncogenic functions. The AurkA kinase is a well-known mitotic regulator, frequently overexpressed in tumors. The microtubule-binding protein TPX2 controls AurkA...
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| Autori principali: | , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Life Science Alliance LLC
2023-05-01
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| Serie: | Life Science Alliance |
| Accesso online: | https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202201726 |
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